Amyvid - Flobetapir F 18

 Amyvid - Florbetapir F-18 - is indicated for PET imaging of the brain to estimate beta-amyloid neuritic plaque density in adult patients with cognitive impairment who are being evaluated for Alzheimer's Disease and other causes of cognitive disease.

A negative Amyvid scan indicates sparse to no nueritic plaques and is inconsistant with neuropathological diagnosis of Alzheimer's Disease at the time of imaging.

A typical negative scan as taken from the Amyvid package inserts demonstrates
A - white matter tracts can be delineated from the frontal lobe to parietal lobe.
B- White matter tracts are clearly identified throughout the occitpal-temporal area.
C - Scalloped appearance is seen with "fingers" of white matter in the frontal cortex.
D - Low levels of tracer in scalp or skull that should be distinguished from gray matter uptake by its shape and position


A positive Amyvid scan indicates moderate to frequent amyloid neuritic plaques.
A - White matter tracts are difficult to fully identify as they travel from frontal to parietal lobe.
B - Borders of white matter tracts in occipital-temporal are are lost in places.
C - Gray metter in medial parietal cortex (precuneus) has increased uptake.
D - Low levels of trace in scalp or skull that should be distinguished from gray matter uptake by its shape and position.

Dose: 10 mCi (370 MBq) in a single bolus in a total volume of 10 mL or less, intravenous.

Contraindications: None

Acquisition: Obtain 10 minute PETCT image starting 30-50 minutes post injection



Beta-amyloid - Amyloid precursor protein is found through out the body. The amyloid hypothesis is that a fault with the processing of amyloid precursor protein in the brain leads to the production of a short fragment of amyloid precursor protein known as beta-amyloid. The accumulation of beta-amyloid trigger disruption and destruction of nerve cells that cause Alzheimer's disease...


In a statement released April 6, 2012, Eli Lilly and Company, Indianapolis, In, announced FDA approval of Amyvid - Florbetapir F-18 injection -  for use in patients being evaluated for Alzheimer's Disease and other causes of cognitive decline.  Amyvid the is the first and only radioactive diagnostic agent approved for PET imaging of beta-amyloid neuritic plaques in living brain.